True isolation is when you become an outsider to your self. When your mind simply can't understand itself and begins to distend and distort. Eventually it fractions itself and the part carrying you keeps itself away from the part that's truly you.
I guess all the art in the world is created as an attempt to bridge those fractions of ourselves. Strangely enough though, through someone else's music every once in a while you catch a glimpse of yourself. One outsider helping another.